In yesterday's post, I mentioned that Dr. Z. lost me during the PGD part of his recommendation. After the appointment, Paul and I talked and preliminarily decided against PGD because of a) the cost (another $5,000-7,000 on top of what we'll already pay), and b) because "it doesn't matter" (since we were only going to try this once, knowing whether our embryos were normal before a BFN (big fat negative pregnancy test) wouldn't change anything).
On the way to work this morning, though, I started thinking about this more. PGD samples a single cell from each 6-8 cell embryo on day 3. This sampling has no impact on a healthy embryo's ability to continue growing and dividing (but can ruin abnormal ones). The results are returned from the outside lab (in Nevada) on the morning of day 5 (embryo transfer day). One or more embryos that tested normally and are high quality are transferred; any extra normal ones that remain can be frozen.
If we do PGD, only those healthy embryos (those free of the main genetic disorders, like Downs (not fatal), Turmers (usually fatal) and Potters (always fatal) chromosomal disorders) would be transferred to my uterus. There's a chance we'd have no healthy embryos, in which case we'd be out the entire $15,000-18,000 for the cycle. At the same time, if we did have healthy embryos and were able to freeze extras, all may not be lost...a BFN the first time could lead to a $3,000 frozen embryo transfer (FET) of one or more *known* genetically normal embryos the next time...therefore knocking our anti-PGD reason "b" out of the water.
PGD is 95-98% accurate. There's a tiny statistical drop in the number of PGD embryos that survive thaw for FET (92-95% versus 97-98%). There is a significant decrease in the miscarriage rate for normal PGD embryos versus regular IVF embryo transfer. Due to my age, it's possible a big portion of my eggs are abnormal, so PGD is actually warranted.
It's too early to say what route we'll take. At this point, Paul is completely unaware of where my brain is on this topic (although I wouldn't be surprised if he's having the exact same thoughts!). I do think further discussion is in order...